Europe Arbeitnow ·
full-timeProtein Production Scientist, Biologics
Substrate Bio · London
LEVEL: Scientist / Senior Scientist · LOCATION: London (20 Triton Street) · PATTERN: In-person, lab-based The opportunity We are building the protein production cascade that turns a sequence into characterised, quality-controlled protein at scale, and you will build it from the first manual run. This is the work upstream of every protein data point we generates: DNA design, molecular biology, protein expression, purification, and quality control, developed by hand and engineered to move onto automation. About us AI for biology has a data problem. The data that matters most doesn’t exist yet, so we’re building the infrastructure to produce it, with quality and traceability built in from day one. We’re in stealth and heads-down on execution. We’ll share more about what we’re building once you’ve spoken with the team. The role You will build the protein production cascade that sits upstream of molecular characterisation and functional assays: DNA design, molecular biology, protein expression, purification, and quality control through analytical characterisation. The cascade will eventually run autonomously on our automation platform. In the first phase, you develop each step by hand, running protocols manually, setting reproducibility and quality thresholds, and proving each phase works before it moves onto instrumentation. As the automation platform comes online, the work shifts toward instrumented execution, equivalence validation, and the engineering judgement calls that decide which manual steps get automated and which stay in human hands. You will work directly with the automation engineering and software teams on the boundary between scientific protocols and autonomous execution, at Scientist or Senior Scientist level, alongside Principal Scientists at the bench, and you will grow into protocol authorship over the first year. What you will do in your first twelve months PHASE 0 · NOW TO AUG 2026 ◆ Land in the lab. Set up your bench at the London site and start manual assay development alongside a senior member of the protein sciences vertical. ◆ Get hands on the first priority protein production workflows as the day-one assay menu locks. ◆ Start building DNA design and production (linear DNA), protein expression (cell-free), and protein purification and QC at high throughput. Run them by hand on equipment that will eventually move onto the automation platform, capturing the data-structure and metadata decisions that translate into automation design. ◆ Build reproducibility, precision, and acceptance thresholds into the workflow. ◆ Contribute to the day-one menu decisions and begin authoring SOPs for your slice of the assay portfolio. Help interview the scientists and lab technicians joining alongside you. PHASE 1 · SEP TO DEC 2026 ◆ Have a linear DNA, cell-free expression, purification, and QC workflow in a semi-automated state, running at the scale of hundreds to thousands per week and ready for full automation. ◆ Co-design protocols with the software and automation engineering teams so the manual versions you validate are automation-ready by design. Decide which manual judgement calls have to be engineered out before they reach the platform. ◆ Start building DNA design and production (plasmid DNA), protein expression (mammalian), and protein purification and QC at high throughput, again by hand on equipment that will move onto the platform. ◆ Build reproducibility, precision, and acceptance thresholds into the workflow. ◆ Contribute to co-design conversations with the first commercial customers, including the foundation-model partners coming online from 2027. PHASE 2 · JAN TO MAR 2027 ◆ Workcells arrive in the lab. Move the validated assays onto them, running with instrumentation and human intervention in the loop. Validate equivalence against your manual baselines and triage failures. ◆ Open the assay menu to customers through manual and semi-automated services. Run real experiments for real customers. ◆ Help bring on the next scientists and lab technicians as the vertical grows. Who you are You are a protein scientist who is excited about the actual work: designing, running, and validating at the bench. You are comfortable in the details. You have hands-on experience with high throughput, plate-based methods across molecular biology, protein expression, purification, and QC. The shape of the problem is what attracts you: assays designed for autonomous execution from day one, in a business where the data the lab produces is itself the product. You write good SOPs, and you hold yourself and your colleagues to clear reproducibility thresholds. You are pragmatic about being hands-on in the early phase, when the cadence is heaviest, and you understand it eases as protocols move onto instrumentation. You enjoy working at the boundary with non-biologist colleagues (automation engineers, software engineers, AI researchers), and you do not require them to be scientifically fluent before you will collaborate.
| Role | Protein Production Scientist, Biologics |
|---|---|
| Company | Substrate Bio |
| Location | London |
| Type | full-time |
| Compensation | Not disclosed |
| Deadline | Rolling |
Typical process for this type of role
A general guide — the exact steps for this specific listing may vary; check the original posting for details.
- 1ApplicationSubmit your resume through the apply link.
- 2ScreeningRecruiter reviews your background against the role.
- 3AssessmentA technical test, assignment, or coding round, depending on the role.
- 4Interview(s)One or more rounds with the hiring team.
- 5OfferOffer letter with compensation and start date.
Before you apply
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